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(R)-Ketamine

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Ketamine occurs as two mirror-image forms: (R)-ketamine and (S)-ketamine. While both interact with NMDA receptors, their balance can influence the character and duration of effects observed in research.

(S)-Ketamine (esketamine): Higher NMDA receptor potency; typically yields more pronounced dissociative/psychedelic effects; approved only in specific regulated formulations and settings.
(R)-Ketamine (arketamine): Lower NMDA potency; preclinical work suggests longer-duration antidepressant signals and fewer acute dissociative/pressor effects; not approved as a standalone therapy.
Recommended Dosages:
- Oral: 200–300 mg
- Intranasal: 30–200 mg
Always approach dosage with caution, ensuring safe and informed use, particularly in a clinical or therapeutic context.

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(R)-Ketamine: Investigational Enantiomer for Neuropsychiatric Research.

(R)-Ketamine (arketamine) is the R-enantiomer of ketamine with a distinct glutamatergic profile versus (S)-ketamine. Preclinical work explores NMDA/AMPA dynamics, mTOR-linked plasticity, and mood-relevant neurocircuitry—while suggesting comparatively gentler acute dissociation in some contexts. Supplied strictly for research use only to qualified laboratories.

(R)-Ketamine Key Features

Enantiomer-specific pharmacology: Lower NMDA receptor potency than (S)-ketamine; active lines of inquiry include AMPA signaling and mTOR-related plasticity.
Translational relevance: Utilized in mechanistic studies of synaptic remodeling and neuroplasticity.
Quality & documentation: High-purity material with COA and batch traceability for consistent results.

Applications

Preclinical neuropharmacology (NMDA/AMPA, mTOR, plasticity)
Comparative enantiomer studies (R- vs S-ketamine)
In-vitro and in-vivo models of mood, cognition, and stress response

Note: Use under professional guidance for safe and effective outcomes. Always adhere to recommended dosages and protocols.

Dosing Guide (This Table is Based on a Person Weighing 70kg)

Dose	Effects
20 mg	Very mild relaxation, slight uplift in mood, minimal sensory changes, almost no dissociation.
40 mg	Mild dissociation, subtle visual shifts, slightly immersive music or sound, still fully functional.
60 mg	Noticeable dissociation, reduced body awareness, slight time distortion, mild K-hole-like sensations possible.
80 mg	Moderate dissociation, internal focus, time distortion, body awareness reduced, can still communicate if needed.
100 mg	Stronger dissociation, pronounced internal experience, mild-to-moderate K-hole, still less intense than equivalent S-ketamine.
120 mg	Deep dissociation, near-K-hole experience, intense internal visual/cognitive focus, still less disorienting than S/racemic.
150 mg	Very strong dissociation, full K-hole possible, profound internal experience, motor control severely impaired.
200 mg	Extreme dissociation, near-anesthesia level, complete loss of environmental awareness, milder acute side effects than racemic/S